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Human papillomavirus (HPV), the virus that causes genital warts, is one of the most common sexually transmitted diseases (STDs). HPV infection can also cause problems with the cervix (the opening to the uterus located at the top of the vagina) that may lead to cervical cancer.

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Both girls and guys can get HPV from sexual contact, including vaginal, oral, and anal sex. Most people infected with HPV don't know it because they have no symptoms. People do not always develop genital warts when they are infected with the virus, but it's still in their system and it could be causing damage. With or without obvious signs like warts, people with HPV might not know they have it and can pass the infection to others.

Because HPV can cause serious problems such as genital warts and cervical cancer, a vaccine is an important step in preventing infection and protecting against the spread of HPV. In June 2006, the U.S. Food and Drug Administration (FDA) approved the vaccine, which protects girls from getting some of the more dangerous strains of HPV.

How Does It Work?

The FDA approved the HPV vaccine as safe for females ages 9 to 26 years old. The vaccine is given as three injections over a 6-month period.

The vaccine does not protect girls who have been infected with HPV before they've been vaccinated. So getting the vaccine before having sex for the first time is the most effective way for it to help prevent the infection. However, the vaccine doesn't protect against all types of HPV, so it's important for girls who are having sex to get routine checkups and, when their doctor recommends it, Pap smears.

The only way to be completely sure about preventing HPV infections and other STDs is not to have sex (called abstinence ). For those who are having sex, condoms offer some protection against HPV. Condoms can't completely prevent infections because the warts can be outside the area covered by the condom (warts are not always clearly seen), and condoms can break.

The HPV vaccine is also not a replacement for using condoms to protect against other STDs when having sex.

Spermicidal foams, creams, and jellies have not been proven to protect against HPV and genital warts. If you have questions about the vaccine or are concerned about STDs, talk to your doctor.

Reviewed by: Larissa Hirsch, MD
Date reviewed: June 2007

Note: All information is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor.

© 1995-2009 The Nemours Foundation/KidsHealth. All rights reserved.

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