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Tumor Necrosis Factor Receptor-Associated Periodic syndrome (commonly referred to as TRAPS) is a hereditary periodic fever syndrome. The former name of this syndrome was Familial Hibernian fever. TRAPS is associated with recurrent episodes of fever with variable duration from a few days to a few months. The frequency of episodes is also quite variable, occurring every 6 weeks in some individuals to every few years in other individuals. Features that can also be seen during episodes include abdominal pain, muscle pain, joint pain, rash and inflammation involving other areas of the body. Approximately 20% of individuals with TRAPS develop an abnormal buildup of the protein amyloid in the kidneys, called amyloidosis. This can result in kidney failure. Individuals with TRAPS typically do not respond to colchicine treatment.
Mutations in the TNFRSF1A gene are associated with TRAPS. TRAPS is inherited in an autosomal dominant manner; only one disease-associated mutation in the TNFRSF1A gene is need to cause features of the condition.
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