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The common F2 c.20210G>A mutation is associated with elevated prothrombin levels, which promotes development of fibrin clots. 2-4 % of the population is heterozygous for this mutation. Heterozygotes may have an estimated 3-11 fold increased risk of thrombosis. The risk of recurrence venous thrombosis recurrence is higher in individuals who also carry other thrombosis risk factors.
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