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Sly syndrome (MPS VII) is a lysosomal storage disorder caused by a deficiency of the enzyme beta-glucuronidase. Deficiency of the beta-glucuronidase enzyme leads to accumulation of heparan, chondroitin and dermatan sulfate in multiple body tissues and can cause coarse facial features, corneal clouding, cardiac involvement, skeletal dysplasia, joint stiffness and developmental delay. Age of onset and clinical severity is variable.
Seattle Children’s provides healthcare for the special needs of children regardless
of race, sex, creed, ethnicity or disability. Financial assistance for medically
necessary services is based on family income and hospital resources and is provided
to children under age 21 whose primary residence is in Washington, Alaska, Montana
Seattle Children’s Hospital, Research