Publications

Meyer-Bahlburg A, Renner ED, Rylaarsdam S, Reichenbach J, Schimke LF, Marks A, Tcheurekdjian H, Hostoffer R, Brahmandam A, Torgerson TR, Belohradsky BH, Rawlings DJ, Ochs HD
Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
The Journal of allergy and clinical immunology , Feb. 2012: 129(2)559-562.e2

Lundgren IS, Englund JA, Burroughs LM, Torgerson TR, Skoda-Smith S
Outcomes and duration of Pneumocystis jiroveci pneumonia therapy in infants with severe combined immunodeficiency.
The Pediatric infectious disease journal , Jan. 2012: 31(1)95-7

López SI, Ciocca M, Oleastro M, Cuarterolo ML, Rocca A, de Dávila MT, Roy A, Fernández MC, Nievas E, Bosaleh A, Torgerson TR, Ruiz JA
Autoimmune hepatitis type 2 in a child with IPEX syndrome.
Journal of pediatric gastroenterology and nutrition , Dec. 2011: 53(6)690-3

Pescovitz MD, Torgerson TR, Ochs HD, Ocheltree E, McGee P, Krause-Steinrauf H, Lachin JM, Canniff J, Greenbaum C, Herold KC, Skyler JS, Weinberg A, Type 1 Diabetes TrialNet Study Group
Effect of rituximab on human invivo antibody immune responses.
The Journal of allergy and clinical immunology , Dec. 2011: 128(6)1295-1302.e5

Marques OC, Arslanian C, Ramos RN, Morato M, Schimke L, Soeiro Pereira PV, Jancar S, Ferreira JF, Weber CW, Kuntze G, Rosario-Filho NA, Costa Carvalho BT, Bergami-Santos PC, Hackett MJ, Ochs HD, Torgerson TR, Marzagão Barbuto JA, Condino-Neto A
Dendritic cells from X-linked hyper-IgM patients present impaired responses to Candida albicans and Paracoccidioides brasiliensis.
The Journal of allergy and clinical immunology , Dec. 2011

Cabral-Marques O, Schimke LF, Pereira PV, Falcai A, de Oliveira JB, Hackett MJ, Errante PR, Weber CW, Ferreira JF, Kuntze G, Rosário-Filho NA, Ochs HD, Torgerson TR, Carvalho BT, Condino-Neto A
Expanding the Clinical and Genetic Spectrum of Human CD40L Deficiency: The Occurrence of Paracoccidioidomycosis and Other Unusual Infections in Brazilian Patients.
Journal of clinical immunology , Dec. 2011

Gambineri E, Torgerson TR
Genetic disorders with immune dysregulation.
Cellular and molecular life sciences : CMLS , 2012 Jan: 69(1)49-58

Meyer-Bahlburg A, Renner ED, Rylaarsdam S, Reichenbach J, Schimke LF, Marks A, Tcheurekdjian H, Hostoffer R, Brahmandam A, Torgerson TR, Belohradsky BH, Rawlings DJ, Ochs HD
Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
The Journal of allergy and clinical immunology , 2011 Oct 24

Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
The Journal of experimental medicine , 2011 Sep 26: 2033-42

Bandaranayake AD, Correnti C, Ryu BY, Brault M, Strong RK, Rawlings DJ
Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.
Nucleic acids research , 2011 Sep 12

Lundgren IS, Englund JA, Burroughs LM, Torgerson TR, Skoda-Smith S
Outcomes and Duration of Pneumocystis jiroveci Pneumonia Therapy in Infants With Severe Combined Immunodeficiency.
The Pediatric infectious disease journal , Aug. 2011

Moratto D, Giliani S, Bonfim C, Mazzolari E, Fischer A, Ochs HD, Cant AJ, Thrasher AJ, Cowan MJ, Albert MH, Small T, Pai SY, Haddad E, Lisa A, Hambleton S, Slatter M, Cavazzana-Calvo M, Mahlaoui N, Picard C, Torgerson TR, Burroughs L, Koliski A, Neto JZ, Porta F, Qasim W, Veys P, Kavanau K, Hönig M, Schulz A, Friedrich W, Notarangelo LD
Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study.
Blood , Aug. 2011: 118(6)1675-84

Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM
Tracking genome engineering outcome at individual DNA breakpoints.
Nature methods , 2011 Jul 10: 671-6

Sather BD, Ryu BY, Stirling BV, Garibov M, Kerns HM, Humblet-Baron S, Astrakhan A, Rawlings DJ
Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.
Molecular therapy : the journal of the American Society of Gene Therapy , 2011 Mar: 515-25

Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR
Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.
PloS one , 2011 Feb 9: e16825

Tsuda M, Torgerson TR, Selmi C, Gambineri E, Carneiro-Sampaio M, Mannurita SC, Leung PS, Norman GL, Gershwin ME
The spectrum of autoantibodies in IPEX syndrome is broad and includes anti-mitochondrial autoantibodies.
Journal of autoimmunity , Nov. 2010: 35(3)265-8

Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , Nov. 2010: 126(5)1000-5

Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , 2010 Nov: 1000-5

Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, Rieber N, Cremer R, Maass E, Dopfer R, Reichenbach J, Wahn V, Hoenig M, Jansson AF, Roesen-Wolff A, Schaub B, Seger R, Hill HR, Ochs HD, Torgerson TR, Belohradsky BH, Renner ED
Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis.
The Journal of allergy and clinical immunology , Sept. 2010: 126(3)611-7.e1

Wang HY, Gopalan V, Aksentijevich I, Yeager M, Ma CA, Mohamoud YA, Quinones M, Matthews C, Boland J, Niemela JE, Torgerson TR, Giliani S, Uzel G, Orange JS, Shapiro R, Notarangelo L, Ochs HD, Fleisher T, Kastner D, Chanock SJ, Jain A
A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency.
Human mutation , Sept. 2010: 31(9)1080-8

Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, Rieber N, Cremer R, Maass E, Dopfer R, Reichenbach J, Wahn V, Hoenig M, Jansson AF, Roesen-Wolff A, Schaub B, Seger R, Hill HR, Ochs HD, Torgerson TR, Belohradsky BH, Renner ED
Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis.
The Journal of allergy and clinical immunology , Sept. 2010: 611-7.e1

Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR, Heink S, Prinz I, Hemmer B, Kuchroo VK, Oukka M, Korn T
γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.
Immunity , 2010 Sep 24: 351-63

Moes N, Rieux-Laucat F, Begue B, Verdier J, Neven B, Patey N, Torgerson TT, Picard C, Stolzenberg MC, Ruemmele C, Rings EH, Casanova JL, Piloquet H, Biver A, Breton A, Ochs HD, Hermine O, Fischer A, Goulet O, Cerf-Bensussan N, Ruemmele FM
Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy.
Gastroenterology , 2010 Sep: 770-8

Wang HY, Gopalan V, Aksentijevich I, Yeager M, Ma CA, Mohamoud YA, Quinones M, Matthews C, Boland J, Niemela JE, Torgerson TR, Giliani S, Uzel G, Orange JS, Shapiro R, Notarangelo L, Ochs HD, Fleisher T, Kastner D, Chanock SJ, Jain A
A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency.
Human mutation , 2010 Sep: 1080-8

Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, Rieber N, Cremer R, Maass E, Dopfer R, Reichenbach J, Wahn V, Hoenig M, Jansson AF, Roesen-Wolff A, Schaub B, Seger R, Hill HR, Ochs HD, Torgerson TR, Belohradsky BH, Renner ED
Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis.
The Journal of allergy and clinical immunology , 2010 Sep: 611-7.e1

Sahni J, Tamura R, Sweet IR, Scharenberg AM
TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes.
Cell cycle (Georgetown, Tex.) , 2010 Sep: 3565-74

Schaller MA, Logue H, Mukherjee S, Lindell DM, Coelho AL, Lincoln P, Carson WF 4th, Ito T, Cavassani KA, Chensue SW, Hogaboam CM, Lukacs NW, Kunkel SL
Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1.
PloS one , 2010 Aug 17: e12172

Lukacs NW, Smit JJ, Mukherjee S, Morris SB, Nunez G, Lindell DM
Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation.
Journal of immunology (Baltimore, Md. : 1950) , 2010 Aug 15: 2231-9

Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE
G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
The Journal of experimental medicine , 2010 Aug 2: 1775-89

Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE
Galphaq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
The Journal of experimental medicine , 2010 Aug 2: 1775-89

Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , July 2010

Paddock MN, Buelow BD, Takeda S, Scharenberg AM
The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.
PLoS biology , 2010 Jul 20: e1000428

Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , 2010 Jul 17

Quan PL, Wagner TA, Briese T, Torgerson TR, Hornig M, Tashmukhamedova A, Firth C, Palacios G, Baisre-De-Leon A, Paddock CD, Hutchison SK, Egholm M, Zaki SR, Goldman JE, Ochs HD, Lipkin WI
Astrovirus encephalitis in boy with X-linked agammaglobulinemia.
Emerging infectious diseases , June 2010: 16(6)918-25

Cavassani KA, Carson WF 4th, Moreira AP, Wen H, Schaller MA, Ishii M, Lindell DM, Dou Y, Lukacs NW, Keshamouni VG, Hogaboam CM, Kunkel SL
The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth.
Blood , 2010 Jun 3: 4403-11

Quan PL, Wagner TA, Briese T, Torgerson TR, Hornig M, Tashmukhamedova A, Firth C, Palacios G, Baisre-De-Leon A, Paddock CD, Hutchison SK, Egholm M, Zaki SR, Goldman JE, Ochs HD, Lipkin WI
Astrovirus encephalitis in boy with X-linked agammaglobulinemia.
Emerging infectious diseases , 2010 Jun: 918-25

Rémy S, Tesson L, Ménoret S, Usal C, Scharenberg AM, Anegon I
Zinc-finger nucleases: a powerful tool for genetic engineering of animals.
Transgenic research , 2010 Jun: 363-71

Huter EN, Natarajan K, Torgerson TR, Glass DD, Shevach EM
Autoantibodies in scurfy mice and IPEX patients recognize keratin 14.
The Journal of investigative dermatology , May 2010: 130(5)1391-9

Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC
Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) , 2010 May 1: 4605-9

Albert MH, Bittner TC, Nonoyama S, Notarangelo LD, Burns S, Imai K, Espanol T, Fasth A, Pellier I, Strauss G, Morio T, Gathmann B, Noordzij JG, Fillat C, Hoenig M, Nathrath M, Meindl A, Pagel P, Wintergerst U, Fischer A, Thrasher AJ, Belohradsky BH, Ochs HD
X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options.
Blood , 2010 Apr 22: 3231-8

Kallal LE, Schaller MA, Lindell DM, Lira SA, Lukacs NW
CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC.
European journal of immunology , 2010 Apr: 1042-52

Yamazaki K, Yamazaki T, Taki S, Miyake K, Hayashi T, Ochs HD, Agematsu K
Potentiation of TLR9 responses for human naïve B-cell growth through RP105 signaling.
Clinical immunology (Orlando, Fla.) , 2010 Apr: 125-36

Tartar DM, VanMorlan AM, Wan X, Guloglu FB, Jain R, Haymaker CL, Ellis JS, Hoeman CM, Cascio JA, Dhakal M, Oukka M, Zaghouani H
FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) , 2010 Apr 1: 3377-85

Suzanne Skoda-Smith, MD
Postgrafting Immune Suppression Combined with Nonmyeloablative
, March 2010

Kerns HM, Ryu BY, Stirling BV, Sather BD, Astrakhan A, Humblet-Baron S, Liggitt D, Rawlings DJ
B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
Blood , 2010 Mar 18: 2146-55

Quintana FJ, Iglesias AH, Farez MF, Caccamo M, Burns EJ, Kassam N, Oukka M, Weiner HL
Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish.
PloS one , 2010 Mar 5: e9478

Kumánovics A, Wittwer CT, Pryor RJ, Augustine NH, Leppert MF, Carey JC, Ochs HD, Wedgwood RJ, Faville RJ Jr, Quie PG, Hill HR
Rapid molecular analysis of the STAT3 gene in Job syndrome of hyper-IgE and recurrent infectious diseases.
The Journal of molecular diagnostics : JMD , 2010 Mar: 213-9

Skoda-Smith S, Torgerson TR, Ochs HD
Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
Therapeutics and clinical risk management , Feb. 2010: 1-10

Skoda-Smith S, Torgerson TR, Ochs HD
Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
Therapeutics and clinical risk management , Feb. 2010: 61-10

Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson BS, Croxford A, Waisman A, Kuchroo VK, Glimcher LH, Oukka M
IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.
Journal of immunology (Baltimore, Md. : 1950) , 2010 Feb 15: 1710-20

Skoda-Smith S, Torgerson TR, Ochs HD
Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
Therapeutics and clinical risk management , 2010 Feb 2: 1-10

Moreno-García ME, Sommer K, Shinohara H, Bandaranayake AD, Kurosaki T, Rawlings DJ
MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
Molecular and cellular biology , 2010 Feb: 922-34

Gruenberg DA, Añover-Sombke S, Gern JE, Holland SM, Rosenzweig SD, Torgerson TR, Seroogy CM
Atypical presentation of IL-12 receptor beta1 deficiency with pneumococcal sepsis and disseminated nontuberculous mycobacterial infection in a 19-month-old girl born to nonconsanguineous US residents.
The Journal of allergy and clinical immunology , Jan. 2010: 125(1)264-5

Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
Immunity , 2010 Jan 29: 129-40

Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT, Workshop Participants
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology , Dec. 2009: 124(6)1152-60.e12

Moreno-García ME, Sommer K, Haftmann C, Sontheimer C, Andrews SF, Rawlings DJ
Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Dec 1: 7362-70

Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT, Workshop Participants
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology , 2009 Dec: 1152-60.e12

Moreno-García ME, Sommer K, Haftmann C, Sontheimer C, Andrews SF, Rawlings DJ
Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Dec 1: 7362-70

Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology , 2009 Dec: 1152-60.e12

Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H, Conley ME, Cunningham-Rundles C, Etzioni A, Hammartröm L, Nonoyama S, Ochs HD, Puck J, Roifman C, Seger R, Wedgwood J
Primary immunodeficiencies: 2009 update.
The Journal of allergy and clinical immunology , 2009 Dec: 1161-78

Peng B, Ye P, Rawlings DJ, Ochs HD, Miao CH
Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
Blood , 2009 Nov 12: 4373-82

Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
Blood , 2009 Nov 5: 4034-44

Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
Blood , 2009 Nov 5: 114(19)4034-44

Marathe BM, Prislovsky A, Astrakhan A, Rawlings DJ, Wan JY, Strom TS
Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
Experimental hematology , 2009 Nov: 1353-63

Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display.
Nucleic acids research , 2009 Nov: 6871-80

d'Hennezel E, Ben-Shoshan M, Ochs HD, Torgerson TR, Russell LJ, Lejtenyi C, Noya FJ, Jabado N, Mazer B, Piccirillo CA
FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome.
The New England journal of medicine , Oct. 2009: 1710-3

Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D
Exploitation of binding energy for catalysis and design.
Nature , 2009 Oct 29: 1300-4

d'Hennezel E, Ben-Shoshan M, Ochs HD, Torgerson TR, Russell LJ, Lejtenyi C, Noya FJ, Jabado N, Mazer B, Piccirillo CA
FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome.
The New England journal of medicine , 2009 Oct 22: 1710-3

Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS
Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Oct 15: 5146-57

Renner ED, Hartl D, Rylaarsdam S, Young ML, Monaco-Shawver L, Kleiner G, Markert ML, Stiehm ER, Belohradsky BH, Upton MP, Torgerson TR, Orange JS, Ochs HD
Coml-Netherton syndrome defined as primary immunodeficiency.
The Journal of allergy and clinical immunology , Sept. 2009: 124(3)536-43

Renner ED, Hartl D, Rylaarsdam S, Young ML, Monaco-Shawver L, Kleiner G, Markert ML, Stiehm ER, Belohradsky BH, Upton MP, Torgerson TR, Orange JS, Ochs HD
Comèl-Netherton syndrome defined as primary immunodeficiency.
The Journal of allergy and clinical immunology , 2009 Sep: 536-43

Alshwaimi E, Purcell P, Kawai T, Sasaki H, Oukka M, Campos-Neto A, Stashenko P
Regulatory T cells in mouse periapical lesions.
Journal of endodontics , 2009 Sep: 1229-33

Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America , 2009 Aug 4: 12885-90

Torgerson TR, Genin A, Chen C, Zhang M, Zhou B, Añover-Sombke S, Frank MB, Dozmorov I, Ocheltree E, Kulmala P, Centola M, Ochs HD, Wells AD, Cron RQ
FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) , July 2009: 183(2)907-15

Buelow B, Uzunparmak B, Paddock M, Scharenberg AM
Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation.
PloS one , 2009 Jul 29: e6339

Torgerson TR, Genin A, Chen C, Zhang M, Zhou B, Añover-Sombke S, Frank MB, Dozmorov I, Ocheltree E, Kulmala P, Centola M, Ochs HD, Wells AD, Cron RQ
FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Jul 15: 907-15

Astrakhan A, Ochs HD, Rawlings DJ
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Jun 15: 7370-80

James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
Science signaling , 2009 May 26: ra25

Awasthi A, Riol-Blanco L, Jäger A, Korn T, Pot C, Galileos G, Bettelli E, Kuchroo VK, Oukka M
Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells.
Journal of immunology (Baltimore, Md. : 1950) , 2009 May 15: 5904-8

Ochs HD, Oukka M, Torgerson TR
TH17 cells and regulatory T cells in primary immunodeficiency diseases.
The Journal of allergy and clinical immunology , 2009 May: 977-83; quiz 984-5

Ochs HD, Oukka M, Torgerson TR
TH17 cells and regulatory T cells in primary immunodeficiency diseases.
The Journal of allergy and clinical immunology , 2009 May: 123(5)977-83; quiz 984-5

Meyer-Bahlburg A, Bandaranayake AD, Andrews SF, Rawlings DJ
Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Apr 1: 4065-75

Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, Sonnenfeld G
Immune responses in adult female volunteers during the bed-rest model of spaceflight: antibodies and cytokines.
The Journal of allergy and clinical immunology , 2009 Apr: 900-5

Tsuboi S, Takada H, Hara T, Mochizuki N, Funyu T, Saitoh H, Terayama Y, Yamaya K, Ohyama C, Nonoyama S, Ochs HD
FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages.
The Journal of biological chemistry , 2009 Mar 27: 8548-56

Andrews SF, Rawlings DJ
Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Mar 1: 2868-78

Edgerton C, Crispín JC, Moratz CM, Bettelli E, Oukka M, Simovic M, Zacharia A, Egan R, Chen J, Dalle Lucca JJ, Juang YT, Tsokos GC
IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice.
Clinical immunology (Orlando, Fla.) , 2009 Mar: 313-21

Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
Clinical immunology (Orlando, Fla.) , Feb. 2009: 130(2)162-74

Salzer U, Bacchelli C, Buckridge S, Pan-Hammarström Q, Jennings S, Lougaris V, Bergbreiter A, Hagena T, Birmelin J, Plebani A, Webster AD, Peter HH, Suez D, Chapel H, McLean-Tooke A, Spickett GP, Anover-Sombke S, Ochs HD, Urschel S, Belohradsky BH, Ugrinovic S, Kumararatne DS, Lawrence TC, Holm AM, Franco JL, Schulze I, Schneider P, Gertz EM, Schäffer AA, Hammarström L, Thrasher AJ, Gaspar HB, Grimbacher B
Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.
Blood , 2009 Feb 26: 1967-76

Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
Clinical immunology (Orlando, Fla.) , 2009 Feb: 162-74

Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL
Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.
Nucleic acids research , 2009 Feb: 877-90

Iyoda M, Hudkins KL, Becker-Herman S, Wietecha TA, Banas MC, Guo S, Meyer-Bahlburg A, Kowalewska J, Liu G, Ziegler SF, Rawlings DJ, Alpers CE
Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
Journal of the American Society of Nephrology : JASN , 2009 Jan: 68-77

Kobayashi S, Haruo N, Sugane K, Ochs HD, Agematsu K
Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings concomitantly with activation-induced cytidine deaminase expression and differentiation into plasma cells.
Human immunology , 2009 Jan: 35-40

Ochs HD
Mutations of the Wiskott-Aldrich Syndrome Protein affect protein expression and dictate the clinical phenotypes.
Immunologic research , 2009: 84-8

Ochs HD, Filipovich AH, Veys P, Cowan MJ, Kapoor N
Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2009 Jan: 84-90

Korn T, Bettelli E, Oukka M, Kuchroo VK
IL-17 and Th17 Cells.
Annual review of immunology , 2009: 485-517

Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC
Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys.
Journal of immunology (Baltimore, Md. : 1950) , 2008 Dec 15: 8761-6

Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
European journal of immunology , 2008 Dec: 3411-25

Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.
Nature immunology , 2008 Dec: 1347-55

Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, Galileos G, Vollmar P, Stritesky GL, Kaplan MH, Waisman A, Kuchroo VK, Oukka M
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America , 2008 Nov 25: 18460-5

Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, Thrasher AJ, Batista FD, Rawlings DJ
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
Blood , 2008 Nov 15: 4158-69

Westerberg LS, de la Fuente MA, Wermeling F, Ochs HD, Karlsson MC, Snapper SB, Notarangelo LD
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.
Blood , 2008 Nov 15: 4139-47

Krueger JG, Ochs HD, Patel P, Gilkerson E, Guttman-Yassky E, Dummer W
Effect of therapeutic integrin (CD11a) blockade with efalizumab on immune responses to model antigens in humans: results of a randomized, single blind study.
The Journal of investigative dermatology , 2008 Nov: 2615-24

Buelow B, Scharenberg AM
Characterization of parameters required for effective use of tamoxifen-regulated recombination.
PloS one , 2008 Sep 23: e3264

Buelow B, Song Y, Scharenberg AM
The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes.
The Journal of biological chemistry , 2008 Sep 5: 24571-83

Lindell DM, Berlin AA, Schaller MA, Lukacs NW
B cell antigen presentation promotes Th2 responses and immunopathology during chronic allergic lung disease.
PloS one , 2008 Sep 3: e3129

Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, Miao CH
Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
Blood , 2008 Sep 1: 1662-72

Feng G, Gao W, Strom TB, Oukka M, Francis RS, Wood KJ, Bushell A
Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells.
European journal of immunology , 2008 Sep: 2512-27

Schultz KA, Neglia JP, Smith AR, Ochs HD, Torgerson TR, Kumar A
Familial hemophagocytic lymphohistiocytosis in two brothers with X-linked agammaglobulinemia.
Pediatric blood & cancer , Aug. 2008: 51(2)293-5

Xiao S, Jin H, Korn T, Liu SM, Oukka M, Lim B, Kuchroo VK
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression.
Journal of immunology (Baltimore, Md. : 1950) , 2008 Aug 15: 2277-84

Lindell DM, Lane TE, Lukacs NW
CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy.
European journal of immunology , 2008 Aug: 2168-79

Schultz KA, Neglia JP, Smith AR, Ochs HD, Torgerson TR, Kumar A
Familial hemophagocytic lymphohistiocytosis in two brothers with X-linked agammaglobulinemia.
Pediatric blood & cancer , 2008 Aug: 293-5

Oxelius VA, Ochs HD, Hammarström L
Restricted immunoglobulin constant heavy G chain genes in primary immunodeficiencies.
Clinical immunology (Orlando, Fla.) , 2008 Aug: 190-8

Renner ED, Rylaarsdam S, Anover-Sombke S, Rack AL, Reichenbach J, Carey JC, Zhu Q, Jansson AF, Barboza J, Schimke LF, Leppert MF, Getz MM, Seger RA, Hill HR, Belohradsky BH, Torgerson TR, Ochs HD
Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome.
The Journal of allergy and clinical immunology , July 2008: 122(1)181-7

Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.
Nature , 2008 Jul 17: 350-2

Renner ED, Rylaarsdam S, Anover-Sombke S, Rack AL, Reichenbach J, Carey JC, Zhu Q, Jansson AF, Barboza J, Schimke LF, Leppert MF, Getz MM, Seger RA, Hill HR, Belohradsky BH, Torgerson TR, Ochs HD
Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome.
The Journal of allergy and clinical immunology , 2008 Jul: 181-7

Sahni J, Scharenberg AM
TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.
Cell metabolism , 2008 Jul: 84-93

Ringold S, Torgerson TR, Egbert MA, Wallace CA
Intraarticular corticosteroid injections of the temporomandibular joint in juvenile idiopathic arthritis.
The Journal of rheumatology , June 2008: 35(6)1157-64

Bettelli E, Korn T, Oukka M, Kuchroo VK
Induction and effector functions of T(H)17 cells.
Nature , 2008 Jun 19: 1051-7

Lukacs NW, Smit JJ, Schaller MA, Lindell DM
Regulation of immunity to respiratory syncytial virus by dendritic cells, toll-like receptors, and notch.
Viral immunology , 2008 Jun: 115-22

Ochs HD
Patients with abnormal IgM levels: assessment, clinical interpretation, and treatment.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology , 2008 May: 509-11

Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor.
Nature , 2008 May 1: 65-71

Torgerson TR
Immune dysregulation in primary immunodeficiency disorders.
Immunology and allergy clinics of North America , 2008 May: 28(2)315-27, viii-ix

Torgerson TR
Immune dysregulation in primary immunodeficiency disorders.
Immunology and allergy clinics of North America , 2008 May: 315-27, viii-ix

Yoo J, Wolgamot G, Torgerson TR, Sidbury R
Cutaneous noncaseating granulomas associated with Nijmegen breakage syndrome.
Archives of dermatology , March 2008: 418-9

Smit JJ, Lindell DM, Boon L, Kool M, Lambrecht BN, Lukacs NW
The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections.
PloS one , 2008 Mar 5: e1720

Notarangelo LD, Rawlings DJ, Sullivan KE
An exemplum of XLA.
Clinical immunology (Orlando, Fla.) , 2008 Feb: 137-9

Meyer-Bahlburg A, Rawlings DJ
B cell autonomous TLR signaling and autoimmunity.
Autoimmunity reviews , 2008 Feb: 313-6

Notarangelo LD, Rawlings DJ, Sullivan KE
An exemplum of XLA.
Clinical immunology (Orlando, Fla.) , 2008 Feb: 137-9

Meyer-Bahlburg A, Rawlings DJ
B cell autonomous TLR signaling and autoimmunity.
Autoimmunity reviews , 2008 Feb: 313-6

Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ
Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
The Journal of experimental medicine , 2008 Jan 21: 155-68

Notarangelo LD, Miao CH, Ochs HD
Wiskott-Aldrich syndrome.
Current opinion in hematology , 2008 Jan: 30-6

Song Y, Buelow B, Perraud AL, Scharenberg AM
Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening , 2008 Jan: 54-61

Meyer-Bahlburg A, Khim S, Rawlings DJ
B cell intrinsic TLR signals amplify but are not required for humoral immunity.
The Journal of experimental medicine , 2007 Dec 24: 3095-101

Fuchizawa T, Adachi Y, Ito Y, Higashiyama H, Kanegane H, Futatani T, Kobayashi I, Kamachi Y, Sakamoto T, Tsuge I, Tanaka H, Banham AH, Ochs HD, Miyawaki T
Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations.
Clinical immunology (Orlando, Fla.) , 2007 Dec: 237-46

Torgerson TR, Ochs HD
Regulatory T cells in primary immunodeficiency diseases.
Current opinion in allergy and clinical immunology , 2007 Dec: 515-21

Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.
Nature immunology , 2007 Dec: 1380-9

Korn T, Oukka M, Kuchroo V, Bettelli E
Th17 cells: effector T cells with inflammatory properties.
Seminars in immunology , 2007 Dec: 362-71

Torgerson TR, Ochs HD
Regulatory T cells in primary immunodeficiency diseases.
Current opinion in allergy and clinical immunology , 2007 Dec: 7(6)515-21

Torgerson TR, Ochs HD
Regulatory T cells in primary immunodeficiency diseases.
Current opinion in allergy and clinical immunology , 2007 Dec: 515-21

Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho IC
Ets-1 is a negative regulator of Th17 differentiation.
The Journal of experimental medicine , 2007 Nov 26: 2825-35

Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler PS, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM
Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
The Journal of cell biology , 2007 Nov 19: 717-31

Sedivá A, Smith CI, Asplund AC, Hadac J, Janda A, Zeman J, Hansíková H, Dvoráková L, Mrázová L, Velbri S, Koehler C, Roesch K, Sullivan KE, Futatani T, Ochs HD
Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L, and DRP2 genes.
Journal of clinical immunology , 2007 Nov: 640-6

Korn T, Anderson AC, Bettelli E, Oukka M
The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis.
Journal of neuroimmunology , 2007 Nov: 51-60

Elyaman W, Bradshaw EM, Wang Y, Oukka M, Kivisäkk P, Chiba S, Yagita H, Khoury SJ
JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) , 2007 Nov 1: 5990-8

Oukka M
Interplay between pathogenic Th17 and regulatory T cells.
Annals of the rheumatic diseases , 2007 Nov: iii87-90

Renner ED, Torgerson TR, Rylaarsdam S, Añover-Sombke S, Golob K, LaFlam T, Zhu Q, Ochs HD
STAT3 mutation in the original patient with Job's syndrome.
The New England journal of medicine , 2007 Oct 18: 1667-8

Renner ED, Torgerson TR, Rylaarsdam S, Añover-Sombke S, Golob K, LaFlam T, Zhu Q, Ochs HD
STAT3 mutation in the original patient with Job's syndrome.
The New England journal of medicine , 2007 Oct 18: 357(16)1667-8

Renner ED, Torgerson TR, Rylaarsdam S, Añover-Sombke S, Golob K, LaFlam T, Zhu Q, Ochs HD
STAT3 mutation in the original patient with Job's syndrome.
The New England journal of medicine , 2007 Oct 18: 1667-8

Scharenberg AM, Humphries LA, Rawlings DJ
Calcium signalling and cell-fate choice in B cells.
Nature reviews. Immunology , 2007 Oct: 778-89

Torgerson TR, Ochs HD
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells.
The Journal of allergy and clinical immunology , 2007 Oct: 744-50; quiz 751-2

Shearer WT, Cunningham-Rundles C, Ballow M, Ochs HD, Geha RS
Images in immunodeficiency.
The Journal of allergy and clinical immunology , 2007 Oct: 982-4

Geha RS, Notarangelo LD, Casanova JL, Chapel H, Conley ME, Fischer A, Hammarström L, Nonoyama S, Ochs HD, Puck JM, Roifman C, Seger R, Wedgwood J
Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee.
The Journal of allergy and clinical immunology , 2007 Oct: 776-94

Scharenberg AM, Humphries LA, Rawlings DJ
Calcium signalling and cell-fate choice in B cells.
Nature reviews. Immunology , 2007 Oct: 778-89

Torgerson TR, Ochs HD
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells.
The Journal of allergy and clinical immunology , 2007 Oct: 120(4)744-50; quiz 751-2

Torgerson TR, Ochs HD
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells.
The Journal of allergy and clinical immunology , 2007 Oct: 744-50; quiz 751-2

Zhong X, Gao W, Degauque N, Bai C, Lu Y, Kenny J, Oukka M, Strom TB, Rothstein TL
Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells.
European journal of immunology , 2007 Sep: 2400-4

Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
The Journal of experimental medicine , 2007 Aug 6: 1775-85

Korn T, Oukka M
Dynamics of antigen-specific regulatory T-cells in the context of autoimmunity.
Seminars in immunology , 2007 Aug: 272-8

Chung DT, Korn T, Richard J, Ruzek M, Kohm AP, Miller S, Nahill S, Oukka M
Anti-thymocyte globulin (ATG) prevents autoimmune encephalomyelitis by expanding myelin antigen-specific Foxp3+ regulatory T cells.
International immunology , 2007 Aug: 1003-10

Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
Nature , 2007 Jul 26: 484-7

Gordon SB, Kayhty H, Molyneux ME, Haikala R, Nurkka A, Musaya J, Zijlstra EE, Lindell D, French N
Pneumococcal conjugate vaccine is immunogenic in lung fluid of HIV-infected and immunocompetent adults.
The Journal of allergy and clinical immunology , 2007 Jul: 208-10

Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C
Novel suppressive function of transitional 2 B cells in experimental arthritis.
Journal of immunology (Baltimore, Md. : 1950) , 2007 Jun 15: 7868-78

Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
The Journal of experimental medicine , 2007 Jun 11: 1257-65

Torgerson TR, Linane A, Moes N, Anover S, Mateo V, Rieux-Laucat F, Hermine O, Vijay S, Gambineri E, Cerf-Bensussan N, Fischer A, Ochs HD, Goulet O, Ruemmele FM
Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene.
Gastroenterology , May 2007: 1705-17

Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ
Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
Nature immunology , 2007 May: 522-31

Torgerson TR, Linane A, Moes N, Anover S, Mateo V, Rieux-Laucat F, Hermine O, Vijay S, Gambineri E, Cerf-Bensussan N, Fischer A, Ochs HD, Goulet O, Ruemmele FM
Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene.
Gastroenterology , 2007 May: 1705-17

Liu P, Scharenberg AM, Cantrell DA, Matthews SA
Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFkappaB activity in vertebrate B-cells.
FEBS letters , 2007 Apr 3: 1377-82

Bettelli E, Oukka M, Kuchroo VK
T(H)-17 cells in the circle of immunity and autoimmunity.
Nature immunology , 2007 Apr: 345-50

Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.
Nature medicine , 2007 Apr: 423-31

Heltzer ML, Choi JK, Ochs HD, Sullivan KE, Torgerson TR, Ernst LM
A potential screening tool for IPEX syndrome.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , March 2007: 10(2)98-105

Heltzer ML, Choi JK, Ochs HD, Sullivan KE, Torgerson TR, Ernst LM
A potential screening tool for IPEX syndrome.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2007 Mar-Apr: 98-105

Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation , Feb. 2007: 117(2)407-18

Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation , 2007 Feb: 407-18

de la Fuente MA, Sasahara Y, Calamito M, Antón IM, Elkhal A, Gallego MD, Suresh K, Siminovitch K, Ochs HD, Anderson KC, Rosen FS, Geha RS, Ramesh N
WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).
Proceedings of the National Academy of Sciences of the United States of America , 2007 Jan 16: 926-31

Sahni J, Nelson B, Scharenberg AM
SLC41A2 encodes a plasma-membrane Mg2+ transporter.
The Biochemical journal , 2007 Jan 15: 505-13

Lukacs NW, Smit J, Lindell D, Schaller M
Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma.
Contributions to microbiology , 2007: 68-82

Ochs HD, Torgerson TR
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance: model for autoaggression.
Advances in experimental medicine and biology , 2007: 27-36

Ochs HD, Gambineri E, Torgerson TR
IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.
Immunologic research , 2007: 112-21

Volná P, Jarjour J, Baxter S, Roffler SR, Monnat RJ Jr, Stoddard BL, Scharenberg AM
Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases.
Nucleic acids research , 2007: 2748-58

Ochs HD, Gambineri E, Torgerson TR
IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.
Immunologic research , 2007: 38(1-3)112-21

Ochs HD, Torgerson TR
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance: model for autoaggression.
Advances in experimental medicine and biology , 2007: 60127-36

Ochs HD, Torgerson TR
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance: model for autoaggression.
Advances in experimental medicine and biology , 2007: 27-36

Ochs HD, Gambineri E, Torgerson TR
IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.
Immunologic research , 2007: 112-21

Song Y, Dayalu R, Matthews SA, Scharenberg AM
TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes.
European journal of cell biology , 2006 Dec: 1253-64

Rawlings DJ, Sommer K, Moreno-García ME
The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
Nature reviews. Immunology , 2006 Nov: 799-812

Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H
Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.
Immunity , 2006 Nov: 745-55

Bartram SA, Peaston RT, Rawlings DJ, Walshaw D, Francis RM, Thompson NP
Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease.
World journal of gastroenterology : WJG , 2006 Sep 21: 5680-6

Lopes JE, Torgerson TR, Schubert LA, Anover SD, Ocheltree EL, Ochs HD, Ziegler SF
Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.
Journal of immunology (Baltimore, Md. : 1950) , 2006 Sep 1: 3133-42

Lopes JE, Torgerson TR, Schubert LA, Anover SD, Ocheltree EL, Ochs HD, Ziegler SF
Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.
Journal of immunology (Baltimore, Md. : 1950) , 2006 Sep 1: 177(5)3133-42

Lindell DM, Ballinger MN, McDonald RA, Toews GB, Huffnagle GB
Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection.
Infection and immunity , 2006 Aug: 4538-48

Torgerson TR
Regulatory T cells in human autoimmune diseases.
Springer seminars in immunopathology , 2006 Aug: 28(1)63-76

Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD
Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
Blood , 2006 Jul 1: 19-27

Winkelstein JA, Marino MC, Lederman HM, Jones SM, Sullivan K, Burks AW, Conley ME, Cunningham-Rundles C, Ochs HD
X-linked agammaglobulinemia: report on a United States registry of 201 patients.
Medicine , 2006 Jul: 193-202

Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
Immunity , 2006 Jun: 741-52

Grubisha O, Rafty LA, Takanishi CL, Xu X, Tong L, Perraud AL, Scharenberg AM, Denu JM
Metabolite of SIR2 reaction modulates TRPM2 ion channel.
The Journal of biological chemistry , 2006 May 19: 14057-65

Tsuboi S, Nonoyama S, Ochs HD
Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.
EMBO reports , 2006 May: 506-11

Ochs HD, Gupta S, Kiessling P, Nicolay U, Berger M
Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases.
Journal of clinical immunology , 2006 May: 265-73

Ochs HD, Gupta S, Kiessling P, Nicolay U, Berger M, Subcutaneous IgG Study Group
Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases.
Journal of clinical immunology , 2006 May: 26(3)265-73

Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, Stray-Pedersen A, Ocheltree EL, Greenberg PD, Ochs HD, Rudensky AY
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.
Proceedings of the National Academy of Sciences of the United States of America , 2006 Apr 25: 6659-64

Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, Stray-Pedersen A, Ocheltree EL, Greenberg PD, Ochs HD, Rudensky AY
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.
Proceedings of the National Academy of Sciences of the United States of America , 2006 Apr 25: 103(17)6659-64

Ochs HD, Thrasher AJ
The Wiskott-Aldrich syndrome.
The Journal of allergy and clinical immunology , 2006 Apr: 725-38; quiz 739

Suzanne Skoda-Smith, MD
Using the pneumococcal conjugate vaccine PCV7 (Prevnar) to evaluate the functional antibody response in adults with recurrent sinopulmonary infections.
, March 2006

Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB
Distinct compartmentalization of CD4+ T-cell effector function versus proliferative capacity during pulmonary cryptococcosis.
The American journal of pathology , 2006 Mar: 847-55

Trakultivakorn M, Ochs HD
X-linked agammaglobulinemia in northern Thailand.
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand , 2006 Mar: 57-63

Araya CE, González-Peralta RP, Skoda-Smith S, Dharnidharka VR
Systemic Epstein-Barr virus infection associated with membranous nephropathy in children.
Clinical nephrology , 2006 Mar: 65(3)160-4

Moreno-García ME, Sommer KM, Bandaranayake AD, Rawlings DJ
Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
Advances in experimental medicine and biology , 2006: : 89-106

Matthews SA, Liu P, Spitaler M, Olson EN, McKinsey TA, Cantrell DA, Scharenberg AM
Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes.
Molecular and cellular biology , 2006 Feb: 1569-77

Rawlings DJ
The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
EMBO reports , 2006 Jan: 25-30

Moreno-García ME, Sommer KM, Bandaranayake AD, Rawlings DJ
Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
Advances in experimental medicine and biology , 2006: 89-106

Aspray TJ, Stevenson P, Abdy SE, Rawlings DJ, Holland T, Francis RM
Low bone mineral density measurements in care home residents--a treatable cause of fractures.
Age and ageing , 2006 Jan: 37-41

Rawlings DJ
The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
EMBO reports , 2006 Jan: 25-30

Nicolay U, Kiessling P, Berger M, Gupta S, Yel L, Roifman CM, Gardulf A, Eichmann F, Haag S, Massion C, Ochs HD
Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home.
Journal of clinical immunology , 2006 Jan: 65-72

Perraud AL, Schmitz C, Scharenberg AM
Calcium signaling, ion channels and more. The DT40 system as a model of vertebrate ion homeostasis and cell physiology.
Sub-cellular biochemistry , 2006: 257-70

Perraud AL, Schmitz C, Scharenberg AM
Analysis of cellular Mg2+ in DT40 cells.
Sub-cellular biochemistry , 2006: 373-8

Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ
Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
Immunity , 2005 Dec: 561-74

Notarangelo LD, Notarangelo LD, Ochs HD
WASP and the phenotypic range associated with deficiency.
Current opinion in allergy and clinical immunology , 2005 Dec: 485-90

Suzanne Skoda-Smith, MD
Systemic Epstein-Barr virus infection-associated membranous nephropathy.
, Nov. 2005

Scharenberg AM
TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors.
Pflugers Archiv : European journal of physiology , 2005 Oct: 220-7

Bindl L, Torgerson T, Perroni L, Youssef N, Ochs HD, Goulet O, Ruemmele FM
Successful use of the new immune-suppressor sirolimus in IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome).
The Journal of pediatrics , 2005 Aug: 256-9

Vogt G, Chapgier A, Yang K, Chuzhanova N, Feinberg J, Fieschi C, Boisson-Dupuis S, Alcais A, Filipe-Santos O, Bustamante J, de Beaucoudrey L, Al-Mohsen I, Al-Hajjar S, Al-Ghonaium A, Adimi P, Mirsaeidi M, Khalilzadeh S, Rosenzweig S, de la Calle Martin O, Bauer TR, Puck JM, Ochs HD, Furthner D, Engelhorn C, Belohradsky B, Mansouri D, Holland SM, Schreiber RD, Abel L, Cooper DN, Soudais C, Casanova JL
Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations.
Nature genetics , 2005 Jul: 692-700

Ochs HD, Notarangelo LD
Structure and function of the Wiskott-Aldrich syndrome protein.
Current opinion in hematology , 2005 Jul: 284-91

Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB
Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection.
Journal of immunology (Baltimore, Md. : 1950) , 2005 Jun 15: 7920-8

Pearce MS, Birrell FN, Francis RM, Rawlings DJ, Tuck SP, Parker L
Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study.
Journal of epidemiology and community health , 2005 Jun: 475-80

Oda A, Miki H, Wada I, Yamaguchi H, Yamazaki D, Suetsugu S, Nakajima M, Nakayama A, Okawa K, Miyazaki H, Matsuno K, Ochs HD, Machesky LM, Fujita H, Takenawa T
WAVE/Scars in platelets.
Blood , 2005 Apr 15: 3141-8

Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD
Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome.
Blood , March 2005: 105(5)1881-90

Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF
Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
Molecular and cellular biology , 2005 Mar: 2073-84

Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L
CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
Journal of immunology (Baltimore, Md. : 1950) , 2005 Mar 1: 2687-95

Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF
Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
Molecular and cellular biology , 2005 Mar: 2073-84

Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD
Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome.
Blood , 2005 Mar 1: 1881-90

Huang W, Ochs HD, Dupont B, Vyas YM
The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement.
Journal of immunology (Baltimore, Md. : 1950) , 2005 Mar 1: 2602-11

Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM
Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels.
The Journal of biological chemistry , 2005 Feb 18: 6138-48

David J. Rawlings, MD
TSLP (Thymic stromal lymphopoietin)
Enclyclopedia of Hormones , 2005

David J. Rawlings, MD
B-Cell Development
Hematology: Basic Principles and Practice , 2005: 119-133

Ochs HD, Ziegler SF, Torgerson TR
FOXP3 acts as a rheostat of the immune response.
Immunological reviews , 2005 Feb: 156-64

Ochs HD, Ziegler SF, Torgerson TR
FOXP3 acts as a rheostat of the immune response.
Immunological reviews , 2005 Feb: 203156-64

Ochs HD, Ziegler SF, Torgerson TR
FOXP3 acts as a rheostat of the immune response.
Immunological reviews , 2005 Feb: 156-64

Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
Genome biology , 2005: R9

Bearden CM, Agarwal A, Book BK, Vieira CA, Sidner RA, Ochs HD, Young M, Pescovitz MD
Rituximab inhibits the in vivo primary and secondary antibody response to a neoantigen, bacteriophage phiX174.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons , 2005 Jan: 50-7

Jin Y, Mazza C, Christie JR, Giliani S, Fiorini M, Mella P, Gandellini F, Stewart DM, Zhu Q, Nelson DL, Notarangelo LD, Ochs HD
Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation.
Blood , 2004 Dec 15: 4010-9

Suzanne Skoda-Smith, MD
A new kindred with X-lined lympho-proliferative disease
, Nov. 2004

Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
The Journal of biological chemistry , 2004 Nov 12: 47720-5

Etzioni A, Ochs HD
The hyper IgM syndrome--an evolving story.
Pediatric research , 2004 Oct: 519-25

Chun HH, Cary RB, Lansigan F, Whitelegge J, Rawlings DJ, Gatti RA
ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
Biochemical and biophysical research communications , 2004 Sep 10: 74-81

Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ
Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
The Journal of biological chemistry , 2004 Sep 3: 37651-61

Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
Blood , 2004 Sep 1: 1281-90

Ochs HD, Notarangelo LD
X-linked immunodeficiencies.
Current allergy and asthma reports , 2004 Sep: 339-48

Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
Molecular therapy : the journal of the American Society of Gene Therapy , 2004 Jul: 117-26

Guo B, Su TT, Rawlings DJ
Protein kinase C family functions in B-cell activation.
Current opinion in immunology , 2004 Jun: 367-73

Ochs HD, Pinciaro PJ
Octagam 5%, an intravenous IgG product, is efficacious and well tolerated in subjects with primary immunodeficiency diseases.
Journal of clinical immunology , 2004 May: 309-14

Schmitz C, Perraud AL, Fleig A, Scharenberg AM
Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms.
Pediatric research , 2004 May: 734-7

Ochs HD, Pinciaro PJ, Octagam Study Group
Octagam 5%, an intravenous IgG product, is efficacious and well tolerated in subjects with primary immunodeficiency diseases.
Journal of clinical immunology , 2004 May: 24(3)309-14

Takezawa R, Schmitz C, Demeuse P, Scharenberg AM, Penner R, Fleig A
Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.
Proceedings of the National Academy of Sciences of the United States of America , 2004 Apr 20: 6009-14

Nieves DS, Phipps RP, Pollock SJ, Ochs HD, Zhu Q, Scott GA, Ryan CK, Kobayashi I, Rossi TM, Goldsmith LA
Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
Archives of dermatology , 2004 Apr: 466-72

Shearer WT, Cunningham-Rundles C, Ochs HD
Primary immunodeficiency: looking backwards, looking forwards.
The Journal of allergy and clinical immunology , 2004 Apr: 607-9

Su TT, Guo B, Wei B, Braun J, Rawlings DJ
Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
Immunological reviews , 2004 Feb: 161-78

David J. Rawlings, MD
Predominant Antibody Deficiencies: X-linked Agammaglobulinemia
Immunologic Disorders of Infants and Children , 2004: 357-373

Su TT, Guo B, Wei B, Braun J, Rawlings DJ
Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
Immunological reviews , 2004 Feb: 161-78

Imai K, Morio T, Zhu Y, Jin Y, Itoh S, Kajiwara M, Yata J, Mizutani S, Ochs HD, Nonoyama S
Clinical course of patients with WASP gene mutations.
Blood , 2004 Jan 15: 456-64

Imai K, Nonoyama S, Ochs HD
WASP (Wiskott-Aldrich syndrome protein) gene mutations and phenotype.
Current opinion in allergy and clinical immunology , 2003 Dec: 427-36

Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL
BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.
Immunity , 2003 Nov: 669-78

Gottlieb AB, Casale TB, Frankel E, Goffe B, Lowe N, Ochs HD, Roberts JL, Washenik K, Vaishnaw AK, Gordon KB
CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study.
Journal of the American Academy of Dermatology , 2003 Nov: 816-25

Lee WI, Zhu Q, Gambineri E, Jin Y, Welcher AA, Ochs HD
Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis.
The Journal of allergy and clinical immunology , 2003 Nov: 958-64

Imai K, Slupphaug G, Lee WI, Revy P, Nonoyama S, Catalan N, Yel L, Forveille M, Kavli B, Krokan HE, Ochs HD, Fischer A, Durandy A
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.
Nature immunology , 2003 Oct: 1023-8

Notarangelo LD, Ochs HD
Wiskott-Aldrich Syndrome: a model for defective actin reorganization, cell trafficking and synapse formation.
Current opinion in immunology , 2003 Oct: 585-91

Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America , 2003 Aug 5: 9470-5

Shi Y, Agematsu K, Ochs HD, Sugane K
Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM.
Clinical immunology (Orlando, Fla.) , 2003 Aug: 128-37

Lejkowski M, Maheshwari A, Calhoun DA, Christensen RD, Skoda-Smith S, Dabrow S
Persistent perianal abscess in early infancy as a presentation of autoimmune neutropenia.
Journal of perinatology : official journal of the California Perinatal Association , July 2003: 428-30

Schmitz C, Perraud AL, Johnson CO, Inabe K, Smith MK, Penner R, Kurosaki T, Fleig A, Scharenberg AM
Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7.
Cell , 2003 Jul 25: 191-200

Gambineri E, Torgerson TR, Ochs HD
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis.
Current opinion in rheumatology , 2003 Jul: 430-5

Gambineri E, Torgerson TR, Ochs HD
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis.
Current opinion in rheumatology , 2003 Jul: 15(4)430-5

Perraud AL, Schmitz C, Scharenberg AM
TRPM2 Ca2+ permeable cation channels: from gene to biological function.
Cell calcium , 2003 May-Jun: 519-31

Suzanne Skoda-Smith, MD
Profiling the non-adherent adolescent heart transplant recipient.
, April 2003

Ballow M, Berger M, Bonilla FA, Buckley RH, Cunningham-Rundles CH, Fireman P, Kaliner M, Ochs HD, Skoda-Smith S, Sweetser MT, Taki H, Lathia C
Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%).
Vox sanguinis , April 2003: 202-10

Kobayashi N, Agematsu K, Sugita K, Sako M, Nonoyama S, Yachie A, Kumaki S, Tsuchiya S, Ochs HD, Sugita K, Fukushima Y, Komiyama A
Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families.
Human genetics , 2003 Apr: 348-52

Matthews SA, Dayalu R, Thompson LJ, Scharenberg AM
Regulation of protein kinase Cnu by the B-cell antigen receptor.
The Journal of biological chemistry , 2003 Mar 14: 9086-91

Rodríguez C, Carrión F, Marinovic MA, Chávez E, Preisler J, Pooley F, Futatani T, Ochs HD
[X-linked hyper-IGM syndrome associated to sclerosing cholangitis and gallbladder neoplasm: clinical case]
Revista medica de Chile , 2003 Mar: 303-8

Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J
B cell developmental requirement for the G alpha i2 gene.
Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb 15: 1707-15

Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM
NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase.
The Journal of biological chemistry , 2003 Jan 17: 1794-801

Monteilh-Zoller MK, Hermosura MC, Nadler MJ, Scharenberg AM, Penner R, Fleig A
TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions.
The Journal of general physiology , 2003 Jan: 49-60

Rafty LA, Schmidt MT, Perraud AL, Scharenberg AM, Denu JM
Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases.
The Journal of biological chemistry , 2002 Dec 6: 47114-22

Torgerson TR, Ochs HD
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulation.
Current opinion in allergy and clinical immunology , 2002 Dec: 481-7

Torgerson TR, Ochs HD
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulation.
Current opinion in allergy and clinical immunology , 2002 Dec: 2(6)481-7

Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America , 2002 Oct 29: 14392-7

Paolini R, Molfetta R, Beitz LO, Zhang J, Scharenberg AM, Piccoli M, Frati L, Siraganian R, Santoni A
Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells.
The Journal of biological chemistry , 2002 Oct 4: 36940-7

Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Blood , Sept. 2002: : 1852-9

Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE, Lenardo MJ
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Nature , Sept. 2002: 395-9

Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Blood , 2002 Sep 1: 1852-9

Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
Nature immunology , 2002 Aug: 780-6

Brunner C, Kreth HW, Ochs HD, Schuster V
Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia.
Journal of clinical immunology , 2002 Jul: 244-51

Su TT, Guo B, Rawlings DJ
Emerging roles for PKC isoforms in immune cell function.
Molecular interventions , 2002 Jun: 141-4

Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP
TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.
Cell , 2002 May 3: 397-407

Aiuti A, Vai S, Mortellaro A, Casorati G, Ficara F, Andolfi G, Ferrari G, Tabucchi A, Carlucci F, Ochs HD, Notarangelo LD, Roncarolo MG, Bordignon C
Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement.
Nature medicine , 2002 May: 423-5

Ochs HD
The Wiskott-Aldrich syndrome.
The Israel Medical Association journal : IMAJ , 2002 May: 379-84

Agematsu K, Futatani T, Hokibara S, Kobayashi N, Takamoto M, Tsukada S, Suzuki H, Koyasu S, Miyawaki T, Sugane K, Komiyama A, Ochs HD
Absence of memory B cells in patients with common variable immunodeficiency.
Clinical immunology (Orlando, Fla.) , 2002 Apr: 34-42

Aranda JM Jr, Scornik JC, Normann SJ, Lottenberg R, Schofield RS, Pauly DF, Miles M, Hill JA, Sleasman JW, Skoda-Smith S
Anti-CD20 monoclonal antibody (rituximab) therapy for acute cardiac humoral rejection: a case report.
Transplantation , March 2002: 907-10

Notarangelo LD, Mazza C, Giliani S, D'Aria C, Gandellini F, Ravelli C, Locatelli MG, Nelson DL, Ochs HD, Notarangelo LD
Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia.
Blood , 2002 Mar 15: 2268-9

Su TT, Rawlings DJ
Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development.
Journal of immunology (Baltimore, Md. : 1950) , 2002 Mar 1: 2101-10

Hermosura MC, Monteilh-Zoller MK, Scharenberg AM, Penner R, Fleig A
Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM.
The Journal of physiology , 2002 Mar 1: 445-58

Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX
A unified nomenclature for the superfamily of TRP cation channels.
Molecular cell , 2002 Feb: 229-31

Inabe K, Ishiai M, Scharenberg AM, Freshney N, Downward J, Kurosaki T
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation.
The Journal of experimental medicine , 2002 Jan 21: 189-200

Ziegner UH, Kobayashi RH, Cunningham-Rundles C, Español T, Fasth A, Huttenlocher A, Krogstad P, Marthinsen L, Notarangelo LD, Pasic S, Rieger CH, Rudge P, Sankar R, Shigeoka AO, Stiehm ER, Sullivan KE, Webster AD, Ochs HD
Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment.
Clinical immunology (Orlando, Fla.) , 2002 Jan: 19-24

Sarpong S, Skolnick HS, Ochs HD, Futatani T, Winkelstein JA
Survival of wild polio by a patient with XLA.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology , 2002 Jan: 59-60

Suzanne Skoda-Smith, MD
Impact of lymphoproliferative disorders after pediatric liver transplant: a single center ten-year experience.
, Oct. 2001

Kang SW, Wahl MI, Chu J, Kitaura J, Kawakami Y, Kato RM, Tabuchi R, Tarakhovsky A, Kawakami T, Turck CW, Witte ON, Rawlings DJ
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
The EMBO journal , 2001 Oct 15: 5692-702

Said JW, Hoyer KK, French SW, Rosenfelt L, Garcia-Lloret M, Koh PJ, Cheng TC, Sulur GG, Pinkus GS, Kuehl WM, Rawlings DJ, Wall R, Teitell MA
TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma.
Laboratory investigation; a journal of technical methods and pathology , 2001 Apr: 555-64

Ziegner UH, Ochs HD, Schanen C, Feig SA, Seyama K, Futatani T, Gross T, Wakim M, Roberts RL, Rawlings DJ, Dovat S, Fraser JK, Stiehm ER
Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies.
The Journal of pediatrics , 2001 Apr: 570-3

Gallagher KT, Shaham B, Reiff A, Tournay A, Villablanca JP, Curran J, Nelson MD Jr, Bernstein B, Rawlings DJ
Primary angiitis of the central nervous system in children: 5 cases.
The Journal of rheumatology , 2001 Mar: 616-23

Skoda-Smith S, Douglas VK, Mehta P, Graham-Pole J, Wingard JR
Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and Rituximab.
Bone marrow transplantation , Feb. 2001: 329-32

Suzanne Skoda-Smith, MD
Pharmacokinetics of a novel IVIG preparation.
, 2001

Suzanne Skoda-Smith, MD
Distinct T-cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of Zap-70.
, 2001

Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A
Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.
Journal of immunology (Baltimore, Md. : 1950) , Jan. 2001: 656-61

Suzanne Skoda-Smith, MD
Donor leukocyte infusions after bone marrow transplantation in children: series from a single institution and review of the literature.
International Journal of Pediatric Hematology/Oncology 7 , 2001: 71-79

Suzanne Skoda-Smith, MD
Current management in child neurology
Vasculitis , 2001

Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T
Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
Journal of immunology (Baltimore, Md. : 1950) , 2000 Aug 1: 1210-9

Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ
Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.
Immunity , 2000 Aug: 243-53

Goldman FD, Gilman AL, Hollenback C, Kato RM, Premack BA, Rawlings DJ
Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties.
Blood , 2000 Jun 1: 3460-6

Gordon MS, Kato RM, Lansigan F, Thompson AA, Wall R, Rawlings DJ
Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.
Proceedings of the National Academy of Sciences of the United States of America , 2000 May 9: 5504-9

Dharnidharka VR, Schowengerdt K, Skoda-Smith S
Failure of combined costimulatory blockade in animal transplant model.
Nature medicine , Feb. 2000: 115

Rawlings DJ
Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.
Clinical immunology (Orlando, Fla.) , 1999 Jun: 243-53

Suzanne Skoda-Smith, MD
Adoptive immunotherapy in children compared to adults.
, May 1999

Mehta P, Kedar A, Graham-Pole J, Skoda-Smith S, Wingard JR
Thalidomide in children undergoing bone marrow transplantation: series at a single institution and review of the literature.
Pediatrics , April 1999: e44

Nisitani S, Kato RM, Rawlings DJ, Witte ON, Wahl MI
In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America , 1999 Mar 2: 2221-6

Fluckiger AC, Sanz E, Garcia-Lloret M, Su T, Hao QL, Kato R, Quan S, de la Hera A, Crooks GM, Witte ON, Rawlings DJ
In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells.
Blood , 1998 Dec 15: 4509-20

Satterthwaite AB, Rawlings DJ, Witte ON
DSHP: a "power bar" for sustained immune responses?
Proceedings of the National Academy of Sciences of the United States of America , 1998 Nov 10: 13355-7

Fluckiger AC, Li Z, Kato RM, Wahl MI, Ochs HD, Longnecker R, Kinet JP, Witte ON, Scharenberg AM, Rawlings DJ
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.
The EMBO journal , 1998 Apr 1: 1973-85

Reiff A, Rawlings DJ, Shaham B, Franke E, Richardson L, Szer IS, Bernstein BH
Preliminary evidence for cyclosporin A as an alternative in the treatment of recalcitrant juvenile rheumatoid arthritis and juvenile dermatomyositis.
The Journal of rheumatology , 1997 Dec: 2436-43

Wahl MI, Fluckiger AC, Kato RM, Park H, Witte ON, Rawlings DJ
Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.
Proceedings of the National Academy of Sciences of the United States of America , 1997 Oct 14: 11526-33

Skoda-Smith S, Mroczek-Musulman E, Galliani C, Atkinson TP, Watts RG
Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.
Archives of pathology & laboratory medicine , Sept. 1997: 996-9

Li T, Rawlings DJ, Park H, Kato RM, Witte ON, Satterthwaite AB
Constitutive membrane association potentiates activation of Bruton tyrosine kinase.
Oncogene , 1997 Sep 18: 1375-83

Skoda-Smith S, Mroczek-Musulman E, Galliani C, Atkinson TP, Watts RG
Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.
Archives of pathology & laboratory medicine , 1997 Sep: 121(9)996-9

Suzanne Skoda-Smith, MD
Reversed phosphorylation T-cell receptor subunits following stimulation of lymphocytes from an immunodeficient patient.
, Feb. 1997

Hannibal MC, Torgerson T, Pagon RA, Bird TD, Dolan CR, Stephens K
IPEX Syndrome
, 1997 - 2004

Rawlings DJ, Quan S, Hao QL, Thiemann FT, Smogorzewska M, Witte ON, Crooks GM
Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro.
Experimental hematology , 1997 Jan: 66-72

Sleasman JW, Aleixo LF, Morton A, Skoda-Smith S, Goodenow MM
CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children.
AIDS (London, England) , Nov. 1996: 1477-84

Afar DE, Park H, Howell BW, Rawlings DJ, Cooper J, Witte ON
Regulation of Btk by Src family tyrosine kinases.
Molecular and cellular biology , 1996 Jul: 3465-71

Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON
Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
Immunity , 1996 May: 515-25

Suzanne Skoda-Smith, MD
Angioedema following dust mite exposure presenting as suspected food allergy.
, Feb. 1996

Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
Science (New York, N.Y.) , 1996 Feb 9: 822-5

Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM
Impaired expansion of mouse B cell progenitors lacking Btk.
Immunity , 1995 Sep: 301-12

Rawlings DJ, Witte ON
The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function.
Seminars in immunology , 1995 Aug: 237-46

Rawlings DJ, Quan SG, Kato RM, Witte ON
Long-term culture system for selective growth of human B-cell progenitors.
Proceedings of the National Academy of Sciences of the United States of America , 1995 Feb 28: 1570-4

Faust EA, Rawlings DJ, Saffran DC, Witte ON
Development of btk transgenic mice.
Current topics in microbiology and immunology , 1995: 363-70

Shahabuddin M, Rawlings DJ, Kaslow DC
A novel glucose-6-phosphate dehydrogenase in Plasmodium falciparum: cDNA and primary protein structure.
Biochimica et biophysica acta , 1994 Sep 13: 191-4

Zhu Q, Zhang M, Rawlings DJ, Vihinen M, Hagemann T, Saffran DC, Kwan SP, Nilsson L, Smith CI, Witte ON, Chen SH, Ochs HD
Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).
The Journal of experimental medicine , 1994 Aug 1: 461-70

Tsukada S, Rawlings DJ, Witte ON
Role of Bruton's tyrosine kinase in immunodeficiency.
Current opinion in immunology , 1994 Aug: 623-30

Saffran DC, Parolini O, Fitch-Hilgenberg ME, Rawlings DJ, Afar DE, Witte ON, Conley ME
Brief report: a point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia.
The New England journal of medicine , 1994 May 26: 1488-91

Rawlings DJ, Witte ON
Bruton's tyrosine kinase is a key regulator in B-cell development.
Immunological reviews , 1994 Apr: 105-19

Rawlings DJ, Bernstein B, Rowland JM, Shaham B, Szer IS
Prolonged course of illness in a child with malignant lymphoma mimicking sarcoidosis.
The Journal of rheumatology , 1993 Sep: 1583-7

Rawlings DJ, Saffran DC, Tsukada S, Largaespada DA, Grimaldi JC, Cohen L, Mohr RN, Bazan JF, Howard M, Copeland NG
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.
Science (New York, N.Y.) , 1993 Jul 16: 358-61

Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.
Cell , 1993 Jan 29: 279-90

Kaslow DC, Rawlings DJ
Introducing restriction sites into double-stranded plasmid DNA.
Methods in enzymology , 1993: 295-301

Scharenberg AM, Hannibal MC, Torgerson T, Ochs HD, Rawlings DJ, Pagon RA, Bird TD, Dolan CR, Stephens K
Common Variable Immune Deficiency Overview
, 1993

Rawlings DJ, Fujioka H, Fried M, Keister DB, Aikawa M, Kaslow DC
Alpha-tubulin II is a male-specific protein in Plasmodium falciparum.
Molecular and biochemical parasitology , 1992 Dec: 239-50

Rawlings DJ, Kaslow DC
Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens.
The Journal of experimental medicine , 1992 Nov 1: 1483-7

Rawlings DJ, Kaslow DC
A novel 40-kDa membrane-associated EF-hand calcium-binding protein in Plasmodium falciparum.
The Journal of biological chemistry , 1992 Feb 25: 3976-82

Yu LS, Versteeg F, Kinoshita M, Yuan B, Bishop N, Torgerson T, Topaz S, Kolff WJ
Soft artificial ventricles for infants and adults, with or without a clamshell.
ASAIO transactions / American Society for Artificial Internal Organs , 1990 Jul-Sep: 36(3)M238-42

Kaslow DC, Rawlings DJ
Rapid method for introducing restriction sites into double stranded plasmid DNA.
Nucleic acids research , 1989 Dec 11: 10135

David J. Rawlings, MD
Immunologic Basics of Hematology Part 2: B-Cell Immunity
Hematology: Basic Principles and Practice. 5th Edition ,

Suzanne Skoda-Smith, MD
Rituximab Administration in Second Trimester of Pregnancy for Kidney Transplant Rejection Results in Suppression of Neonatal B-Cell Development
,

Suzanne Skoda-Smith, MD
Anti-CD20 monoclonal antibody for the treatment of post-transplant lymphoproliferative disease in a pediatric heart transplant recipient.
,

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