GI The Gastroenterology (GI) and Hepatology Research Program is dedicated to shaping the way we understand and care for children with gastrointestinal illnesses. Our investigators are conducting clinical studies that range from deepening our understanding of liver disease to finding new treatments for inflammatory bowel disease.

We invite children and their families to participate in our studies. By participating in a research study, your child will have access to some of the latest GI treatment and therapies, and receive support and care from our research team.

Below is a list of our research efforts.


As one of 14 pediatric hospitals in the world participating in a study on childhood pancreatitis, our investigators' work aims to better understand recurrent and chronic pancreatitis in children. The goal of this research, funded by the National Institutes of Health (NIH), is to create better treatments for pancreatitis. Learn more about the INSPPIRE Pediatric Pancreatitis Research Project.

Inflammatory Bowel Disease (IBD)

As the first research center in the United States to receive federal approval to test the effectiveness of fecal transplants in pediatric patients with IBD, we are one of the only centers researching this treatment. We are also studying new treatments and special diets to manage the symptoms of IBD. Learn more.

Seattle Children's is also part of a national network called ImproveCareNow. In collaboration with other research centers and hospitals, we are analyzing and collecting data to improve the care of children with ulcerative colitis and Crohn's disease.

Viral Hepatitis

Our investigators are studying cutting-edge therapies for hepatitis B and hepatitis C. As a member of the Hepatitis B Research Network (HBRN), a group of seven pediatric centers from around North America, we are partnering to better understand these persistent infections and develop therapies for the HBV virus.

Fatty Liver Disease

As one of eight pediatric clinical centers of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), we are studying and collecting data to learn more about nonalcoholic steatohepatitis (NASH) and conducting clinical studies on prevention and treatment. Seattle Children's is one of eight clinical centers in the NASH Clinical Research Network.

Cholestatic Liver Disease

Our investigators are part of the Childhood Liver Disease Research and Education Network (CHiLDREN) and are studying multiple types of cholestatic liver disease to provide a better understanding of these rare conditions and improve treatments available for them.

Pediatric Acute Liver Failure

Seattle Children's is one of 12 hospitals in the NIH-sponsored multicenter Pediatric Acute Liver Failure (PALF) study group, whose efforts aim to improve how we care for patients with acute liver failure.

Liver Transplant

Seattle Children's is an active member of the Studies of Pediatric Transplantation (SPLIT) study group. This multicenter study has data on more than 2,000 liver transplants in children; the goal is to collect and analyze this information to improve the care of pediatric liver patients. SPLIT provides vital data to the pediatric transplant community, including a better understanding of the issues patients and their families face.  

Short Bowel Syndrome

Our team is conducting research studies on short bowel syndrome so that we may better understand this rare disorder and discover better treatment options for our patients.

Participate in Research

Help us answer questions about childhood health and illness, and help other children in the future. Learn more.

Ways to Help

Private donations help our researchers launch studies that could lead to lifesaving treatments. Email us to learn about supporting Gastroenterology’s research.