PLAT-04 is a phase 1 trial that tests the safety and feasibility of CAR T cells that have been reprogrammed to target the CD22 protein expressed by some leukemia cells.
The PLAT-02 trial uses CAR T cells that have been reprogrammed to target the CD19 protein. However, in some patients, the leukemia comes back (recurs) and has evolved so it doesn’t express CD19 anymore, but it continues to express another protein, CD22.
Our researchers developed PLAT-04 as an investigational treatment option that will hopefully lead to long-term remission for patients whose cancer expresses CD22.
Read the complete PLAT-04 study protocol at clinicaltrials.gov.
Learn more about this and other clinical trials at Seattle Children's.
For more information, call 206-987-2106 or send us an email.